RLO: Plasma Proteins and Drug Distribution

 

Types of Plasma Protein

Most, but not all, plasma proteins are manufactured in the liver including albumins. These are the most abundant and form about 60% of all plasma proteins. They contribute to osmotic pressure, help to control water balance and are involved in the transport of substances in blood including drugs. Globulins (globular proteins) form 35% of the whole and include antibodies, whilst others have transport functions. Approximately 4% of plasma proteins, such as fibrinogen, have a clotting function whilst the remaining less than 1% are regulatory such as metabolic enzymes.

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